Wenhui Tang

Wenhui Tang

I am a 

I am a postdoc at Harvard Medical School, working with Olivier Pourquié and L. Mahadevan. I received my PhD from MIT Mechanical Engineering in May 2024, advised by Ming Guo.

My research uncovers the spatial and temporal organization in complex multicellular systems from biophysics and mechanics perspectives, and how these physical principles apply in tissue engineering and developmental biology. Currently, I am investigating the rhythm of multicellular living systems and pattern formation during morphogenesis.

Focus Areas

Current Work

Developmental Biology

Human Somitogenesis & Organoid Models

Studying segmentation clock dynamics and somite self-organization in iPSC-derived somitoid organoids, bridging in vitro mechanics with in vivo vertebrate patterning.

Somitoids Segmentation Clock iPSC
Biophysics

Oscillatory Synchrony in Multicellular Systems

Modeling Notch/Wnt/FGF pathway coupling and entrainment using Kuramoto oscillator frameworks, combined with confocal imaging and agent-based simulations.

Kuramoto Model Phase Dynamics MATLAB
Computational Methods

3D Segmentation & Quantitative Imaging

Developing pipelines for 3D cell volume segmentation from confocal z-stacks and multi-species comparative analysis of somite size and scaling across vertebrates.

Confocal Microscopy 3D Segmentation Python
Research

Publications

  1. arXiv
    Collective Synchrony in Confluent, Pulsatile Epithelia
    Wenhui Tang, Mehrana R. Nejad, Adrian F. Pegoraro, L. Mahadevan, and Ming Guo
    arXiv preprint, 2025
    arXiv
  2. Phys. Rev. X
    Topology and Nuclear Size Determine Cell Packing on Growing Lung Spheroids
    Wenhui Tang, Jessie Huang, Adrian F. Pegoraro, James H. Zhang, Yiwen Tang, Darrell N. Kotton, Dapeng Bi, and Ming Guo
    Physical Review X, 2025
    DOI
  3. Nature Physics
    Collective Curvature Sensing and Fluidity in Three-Dimensional Multicellular Systems
    Wenhui Tang, Amit Das, Adrian F. Pegoraro, Yu Long Han, Jessie Huang, David A. Roberts, Haiqian Yang, Jeffrey J. Fredberg, Dapeng Bi, L. Mahadevan, and Ming Guo
    Nature Physics, 2022
    DOI
  4. PNAS
    Configurational Fingerprints of Multicellular Living Systems
    Haiqian Yang, Adrian F. Pegoraro, Yulong Han, Wenhui Tang, Rohan Abeyaratne, Dapeng Bi, and Ming Guo
    Proceedings of the National Academy of Sciences, 2021
    DOI
  5. Nature Physics
    Cell Swelling, Softening and Invasion in a Three-Dimensional Breast Cancer Model
    Yu Long Han, Adrian F. Pegoraro, Hui Li, Kaifu Li, Yuan Yuan, Guoqiang Xu, Zichen Gu, Jiawei Sun, Yukun Hao, Satish Kumar Gupta, Yiwei Li, Wenhui Tang, Haiqian Yang, Dapeng Bi, Jeffrey J. Fredberg, and Ming Guo
    Nature Physics, 2020
    DOI
  6. Phys. Rev. E
    Optical Tweezer Measurements of Asymptotic Nonlinearities in Complex Fluids
    Satish Kumar Gupta, Kyle R. Lennon, Mary A. Joens, Hari Bandi, Martijn van Galen, Yulong Han, Wenhui Tang, Yiwei Li, Stephen Spector, James Swan, and Ming Guo
    Physical Review E, 2021
    DOI
  7. Matter
    The Cell as Matter: Connecting Molecular Biology to Cellular Functions
    Yiwei Li, Wenhui Tang, and Ming Guo
    Matter, 2021
    DOI
  8. Int. J. Heat Mass Transfer
    Natural Convection Heat Transfer in a Nanofluid-Filled Cavity with Double Sinusoidal Wavy Walls of Various Phase Deviations
    Wenhui Tang, M. Hatami, Jiandong Zhou, and Dengwei Jing
    International Journal of Heat and Mass Transfer, 2017
    DOI

For a complete list, visit my Google Scholar profile →